Asian and European stock markets opened lower Thursday as oil prices remained above $100 per barrel, driven by escalating Middle East tensions. Investors are bracing for a prolonged conflict following recent developments in the Iran-related regional crisis. S&P 500 futures also declined in pre-market trading.

The surge in crude oil prices has reignited inflation concerns across global markets, prompting speculation about central bank policy responses. European gas prices jumped alongside oil, adding pressure to energy-sensitive sectors. The sustained elevation in energy costs threatens to complicate monetary policy decisions as central banks weigh rate adjustments.

Brent crude futures held firm above the $100 threshold, marking a significant psychological level for energy markets. Asian markets from Tokyo to Hong Kong posted declines, while European indices prepared for their second consecutive weekly drop. Bond markets also reflected the risk-off sentiment with yields moving higher.

The market volatility underscores investor uncertainty about the conflict's duration and economic impact. Energy-dependent industries face particular pressure as higher input costs threaten profit margins. Analysts warn that sustained oil price elevation could derail economic growth forecasts and complicate inflation targeting efforts globally.